History of the Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Y. Kh. Turalulov

The Institute of Endocrinology of the Ministry of Health of the Republic of Uzbekistan was founded in 1989 through reorganization Institute of Regional Medicine, which was created as part of the Academy of Sciences of the Republic of Uzbekistan in 1957. The need for scientific development of medical problems of the region was extremely important not only from the point of view of the interests of the development of medical science at the level of the requirements of that time, but to a greater extent for solving pressing issues practical health care. To solve these problems, it was necessary to have a sufficient number of qualified personnel in all specialties of medical science and practical health care, as well as technically equipped scientific laboratories. It was also necessary to determine the main scientific directions future research. In this regard, the idea arose of creating such a scientific institution in the system of the Academy of Sciences of the Republic of Uzbekistan. The initiator was an outstanding scientist, organizer of science of the Republic, academician H.M. Abdullaev, president of the Academy of Sciences of Uzbekistan in those years. The idea was warmly supported by the first Uzbek medical professors, heads of departments of Tashkent State Medical Institute A.A. Askarov, Z. I. Umidova, N.I.Ismailov, S.A. Masumov and others.

The main problem facing medical science and healthcare practice in those years was the task of eliminating endemic goiter, treatment and prevention of gastrointestinal diseases, vitamin deficiencies; study of the features of water-salt metabolism in conditions hot climate of Central Asia. These problems were put forward as the main scientific directions for the future institute. Presidium of the Academy of Sciences of the Republic of Uzbekistan at for the support of medical scientists, appealed to the Government of the Republic with a proposal to organize a scientific research institute of medical profile in the system of the Academy of Sciences of the Republic of Uzbekistan.

The Institute of Regional Medicine was established by the resolution of the Council of Ministers of the Republic of August 1, 1957. A young, energetic and talented scientist Yalkin Khalmatovich Turakulov was appointed director of the institute. Thanks to erudition and scientific intuition Ya.Kh. Turakulova, in a short time the structure of the institute was formed, including laboratories of pharmacology (headed by associate professor I.K. Kamilov), physiology (head academician A.Yu. Yunusov), clinical pharmacotherapy (head associate professor N.S. Kelginbaev), oriental medicine (associate professor A. Ibragimov), biochemistry (associate professor Ya.Kh. Turakulov), gastrointestinal pathology (head of the corresponding member of the Academy of Sciences of the Republic of Uzbekistan A.A. Askarov), microbiology, pathomorphology, etc. In addition, the Republican anti-throat dispensary of the Ministry of Health was transferred to the institute. In a short time, these laboratories have become in large research centers not only in the system of the Academy of Sciences, but became the basis for the development of departments and experimental directions in medical and biological educational institutions.

The founder of the development of the problem of combating endemic goiter in the Republic was professor of TashMI, surgeon S.A. Masumov, and on the basis of his previous research on endemic goiter in the Fergana Valley, a doctrine was created on the prevention and elimination of goiter by providing the population iodized salt. It was on his initiative that the Republican anti-throat dispensary was organized, which formed the basis of the goiter department when organizing Institute of Regional Medicine. The study of the epidemiology of iodine deficiency and the elimination of endemic goiter became the main focus of the new institute. The name of the institute - the Institute of Regional Medicine was determined based on the tasks of studying the diseases of the region, common in those years (endemic goiter, gastrointestinal diseases, vitamin deficiencies). But in view of the extreme urgency of endemic goiter, the emphasis was placed on the elimination of iodine deficiency.

By the end of 1957, the Institute of Regional Medicine had eight laboratories: physiology, pharmacology, biochemistry, gastrointestinal pathology with a hospital, endemic goiter with a surgical department, pathology, bacteriology. In 1958, under the leadership eminent scientist, specialist in food hygiene prof. Makhkamova G.M. a laboratory of nutrition and experimental pathology was created, which began closely deal with the peculiarities of preparing oriental dishes, hygienic requirements for the composition of nutritious products and cooking technology, vitamin provision.

The main achievements of the laboratory of biochemistry, thyroid pathology, laboratory and clinic of the thymus department in the early years were associated with the study of iodine metabolism and they were achieved largely due to the widespread use of the radioactive isotope of iodine I131 for diagnostic (radioiodine diagnostics), therapeutic (radioiodine therapy) and research purposes. The Institute of Regional Medicine has provided invaluable assistance to many institutes of biological divisions of the Academy of Sciences of the Republic of Uzbekistan, clinics and departments in the training of specialists, the organization of a laboratory of radioactive isotopes.

In subsequent years, the Institute of Regional Medicine of the Ministry of Health of the Republic of Uzbekistan, despite the expansion of the topic, repeated transitions from the system Of the Academy of Sciences of the Republic of Uzbekistan to the health care system and back, retained its leading position as a scientific center for the study of the exchange of iodine in the body and iodine deficiency states, the use of radioactive iodine in medicine, not only in the republic, but also in neighboring Central Asian countries. During the period of the Institute Regional medicine was constantly looking for new directions, they were developed, modified. Talented people took part in their creation and development energetic mature scientists and they have left an unforgettable mark on the history of laboratories and clinical departments. Recognized therapist-endocrinologist Erkin Gafurovich Kayumov, who led the therapeutic direction at the clinic, began the first research on diabetes mellitus, was one of the first doctoral students of the Institute and defended his doctoral dissertation in consultation with the famous scientist, academician of the Academy of Medical Sciences, founder of the school of diabetologists prof. Baranova V.G.

Dr. med. prof. Kelginbaev Niyaz Suleimanovich created a laboratory of clinical pharmacotherapy, later on the basis of which was the laboratory of diabetology was established. Prof. Rakhimov Nishan Rakhimovich, a well-known therapist-gastroenterologist, who led the Academician A.A. Askarov of the Department of Gastrointestinal Pathology, was the director of the Institute in 1974-1975 and ensured the development of the gastroenterological direction.

Ilyasov Sh.Sh. - student of prof. Masumova S.A., a surgeon-endocrinologist, has done a lot of scientific, epidemiological work on thyroid pathology. In 1975 he was director of the Institute.

Achievements in these areas were significant enough and in 1964 they were awarded the highest scientific award time - the Lenin Prize in the field of science - thanks to the results of clinical and biochemical studies of endemic goiter, performed by Ya.Kh. Turakulov, R.K. Islambekov. The first book devoted to iodine metabolism and thyroid hormones was published in 1960 by Ya.Kh. Turakulov, the book was published in English language. In fact, it was the main achievement of the Institute's research on regional pathology.

The creation of the Institute of Regional Medicine of the Academy of Sciences of the Republic opened up huge new opportunities for training national personnel in the field of various branches of medicine and biology. The training of personnel was carried out not only within the walls of the laboratory of the institute, but also by secondment full-time graduate students and doctoral students in the leading scientific centers of the former Soviet Union. Over 50 years of the Institute's existence, a huge number of candidates have been prepared and doctors of science published monographs, collections of methodological documents of popular science publications, scientific articles in domestic and foreign journals. In 1967, the Institute of Biochemistry, then the Institute of Physiology, a number of departments in medical, pharmaceutical institutes, at the Tashkent State University. New methods penetrated into biochemical research through the Institute of Regional Medicine biochemical, biophysical, cytological studies, radioisotope-histochemical analysis, different variants of chromatography, electrophoresis, luminescent and phase contrast microscopy.

Leading scientists of the Institute take an active part in international scientific conferences, symposia and congresses. If, before the Republic gained independence, the participation of employees in International conferences was sporadic and rare, then for the last ten years gave a huge impetus to communicate with leading experts around the world. The presence of the Internet allows you to be in the thick of the latest achievements in medicine. Established close ties with leading scientists from Russia, USA, England, Germany, France, Japan, Australia and other countries.

Consistent and thoughtful development and expansion of clinical departments, a polyclinic, a radiological building Clinics of the Institute of Endocrinology into a qualified scientific and practical endocrinological center, recognized in the Republic. Clinic Development The Institute was accompanied by the creation of a material base and equipping departments with modern equipment, training qualified scientific personnel, endocrinologists. In accordance with the new status after the transformation of the Institute of Regional Medicine into the Institute of Endocrinology and full development of the clinical corps, the scope of its responsibilities has expanded, the level, volume and depth of diagnostic, therapeutic, preventive work, new laboratories have been created, clinical departments.

Based on the Decree of the President of the Republic of Uzbekistan dated September 19, 2007 No. UP-3923 “On the main directions of further deepening reforms and implementation of the State Program for Healthcare Development "and the Resolution of the President of the Republic of Uzbekistan dated October 2, 2007 № PP-700 "On measures to improve the organization of the activities of medical institutions of the republic" Research Institute of Endocrinology The Ministry of Health of the Republic of Uzbekistan was reorganized into the Republican Specialized Scientific and Practical Medical Center of Endocrinology.

LIST OF DOCTORS OF SCIENCES WORKING IN THE CENTER

TURAKULOV YALKIN KHOLMATOVICH - Doctor of Biological Sciences, Professor, Academician, Honored Scientist, Laureate of the prestigious State Prize of the former Soviet Union.

ABDULLAEV NUSRAT KHAMIDOVICH - Dr. med. sciences, professor.

ABIDOV ALIM ABIDOVICH - Doctor of Medical Sciences, Professor.

ARTEMOVA EVGENIYA PAVLOVNA - Doctor of Biological Sciences.

GULYAMOV TURADZHAN DADADZHANOVICH - Doctor of Medical Sciences.

DEKHKANKHODJAYEVA NAZMINISSO ABDULLAEVNA - Doctor of Medical Sciences sciences, professor.

ZUFAROV KAMILDZHAN AKHMEDZHANOVICH - Doctor of Medical Sciences, Professor, Academician

ISLAMBEKOV RAJAB KAPLANOVICH - Doctor of Medical Sciences. Professor, Corresponding Member of the Russian Academy of Medical Sciences, Honored Scientist, Laureate of the prestigious State Prize of the former Soviet Union.

ISMAILOVA VASILYA NASYROVNA - Doctor of Medical Sciences, Professor.

IBRAGIMOV TAKHIR KUDRATOVICH - Doctor of Medical Sciences.

KELGINBAEV NIYAZ SULEIMANOVICH - Doctor of Medical Sciences, Professor.

KOKUEVA OLGA VASILIEVNA - Doctor of Medical Sciences.

MAKHKAMOV GULYAM MAKHKAMOVICH - Doctor of Medical Sciences, Professor, Honored Doctor of the Republic.

MURTAZAEVA LILIYA ASANOVNA - Doctor of Biological Sciences.

RAKHIMOV NISHAN RAKHIMOVICH - Doctor of Medical Sciences, Professor.

RAKHIMOVA DILOROM ZAKIROVNA - Doctor of Medical Sciences, Professor.

KHARATYAN ALFRED MIKHAILOVICH - Doctor of Medical Sciences.

FATKHULLAEV ISMATULLA FATKHULLAEVICH - Doctor of Medical Sciences.

YUNUSOV ADKHAM YUNUSOVICH - Doctor of Biological Sciences, Professor, Academician.

YULDASHEV KARIM YULDASHEVICH - Doctor of Medical Sciences, Professor, Academician.

NUGMANOVA LARISA BAKHRAMOVNA - doctor med. sciences, professor.

LIST OF DOCTORS OF SCIENCE WORKING IN THE CENTER

ALIMOV ANVAR VALIEVICH - doctor of medical sciences, professor.

AKBAROV ZAIR SOBIROVICH - doctor of medical sciences, professor.

MUKHAMEDOV TUHTAMURAD MUKHAMEDOVICH - doctor of medical sciences

RAKHIMOVA GULNARA NISHANOVNA - doctor of medical sciences

KHALIMOVA ZAMIRA YUSUPOVNA - doctor of medical sciences.

SALAKHOVA NAZIRA SAGDULLAEVNA - doctor of medical sciences. professor.

URMANOVA YULDUZ MAHKAMOVNA - doctor of medical sciences

KHAYDAROVA FERUZA ALIMOVNA - doctor of medical sciences science.

LIST OF DIRECTORS

1957-1958	Director of the Research Institute of Regional Medicine of the Academy of Sciences of the Republic of Uzbekistan Turakulov Yalkin Kholmatovich.
1958-1966	Director of the Institute of Regional Experimental Medicine Makhkamov Gulyam Makhkamovich.
1967-1971	Director of the Research Institute of Regional Medicine of the Ministry of Health of the Republic of Uzbekistan Islambekov Rajab Kaplanovich.
1972-1973	Director of the Research Institute of Regional Medicine Zufarov Kamiljan Akhmedzhanovich.
1974	Director of the Research Institute of Regional Medicine of the Ministry of Health of the Republic of Uzbekistan Jalal Nasyrovich Maksumov.
1974-1975	Director of the Research Institute of Regional Medicine of the Ministry of Health of the Republic of Uzbekistan Rakhimov Nishan Rakhimovich.
1975-1976	Director of the Research Institute of Regional Medicine of the Ministry of Health of the Republic of Uzbekistan Ilyasov Shokasym Shahizirovich.
1976-1997	Director of the Institute of Endocrinology of the Academy of Sciences of the Republic of Uzbekistan Turakulov Yalkin Holmatovich.
1997-2015	Director of RSNPMTSE MH RUz Ismailov Said Ibrahimovich. On behalf of the Board of Directors and Staff of the International Diabetes Federation, we would like to express our sincerest condolences on the passing of Professor Said Ismailov. Prof. Ismailov dedicated himself to the cause of diabetes, especially in Uzbekistan. He will be greatly missed and will remain a source of inspiration for people with diabetes. Our thoughts are with Prof Ismailov's family and friends, and with the Endocrinological and Diabetes Association of Uzbekistan . With deep respect and our most heartfelt sympathy.
C 2015	Director of RSNPMTSE MH RUz Alimov Anvar Valievich

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1957	The Institute was organized under the system of the Academy of Sciences of Uzbekistan in accordance with the Government Decree (No. 481 of August 1, 1957
1957-1967	The Institute was under the jurisdiction of the USSR Academy of Medical Sciences
1967	The Institute was transferred to the system of the Academy of Sciences of the Uz SSR and in the same year it was transferred to the Ministry of Health of the Uz SSR (Decree of the Central Committee of the Collective Committee and the CM of the Uz SSR No. 211 of May 6, 1967)
1958	8 laboratories functioned and they used isotopes for the first time, superimposed radiochromatography, autoradiography, radioiodine diagnostics, luminescence and phase contrast microscopy.
1959	The department of oriental medicine has been created and the study of mumiyo and a number of glycosides has begun.
1959-1961	The Institute has published 8 monographs, 3 textbooks, 4 collections and 217 articles.
1959	The institute had 40 postgraduate students, and by 1961 there were already -62.
1964	Ya.Kh. Turakulov and R.K. Islambekov were awarded the highest State Prize.
1965	Scientific potential of the institute - 95 researchers, 6 doctors and 40 candidates of med. sciences.
1966	24 PhD theses defended.
1967-1968	The Institute of Biochemistry and the Institute of Physiology of the Academy of Sciences of Uz.
1969	There are 3 departments in the structure of the institute - gastroenterology, endocrinology and pharmacotherapy with 13 laboratories.
1971	The institute moves to a new building with a clinic expanded to 165 beds.
1975	Created surgical endocrinology for 20 beds.
1977	The Republican anti-throat dispensary has been attached to the institute.
1979	For the first time a laboratory of pediatric endocrinology was organized.
1980	A radiological department opens for the first time in Central Asia and radioiodine is used in the treatment and diagnosis of thyroid diseases.
1980	By the decision of the Pharmaceutical Committee of the USSR (16.U.80), a clinical trial of mumiyo is allowed.
1983	Diabetology laboratory created.
1986	Cryopreservation and transplantation of endocrine glands, as well as express histomorphology. The Thyroid Pathology Laboratory was renamed the Endocrine Surgery Laboratory.
1987	4 expositions at VDNKh Uz SSR were awarded with diplomas of 2-3 degrees.
1989	The construction of a new building has been completed and an intensive care unit with 6 beds is opening.
1989	The Institute of Regional Medicine was reorganized into the Research Institute of Endocrinology, Ministry of Health of the Republic of Uzbekistan.
1990	The first laboratory for radioimmunoassay was created.
1996	Based on the existing GGR, a laboratory of neuroendocrinology was created
1998	With the change in the structure of the institute, clinical and experimental thyroidology was created.
2003-2004	On the basis of general endocrinology, a department of reproductive endocrinology, a department of diabetic nephropathy and diabetic foot was created.
2004	in the structure of the institute there are 6 scientific laboratories, a clinic with 10 departments for 246 beds, a polyclinic for 250 visits, an organizational method department and other units.
2006	18 employees visited 24 foreign business trips in 11 foreign countries in order to exchange experience and participate in international forums.
2007	The scientific potential of the institute has 7 doctors, of which 3 are professors and 15 are candidates of med. sciences.
2007	The Institute cooperates with scientists from Russia, England, USA, Germany, France, Japan, Czech Republic.
2007	The Institute was renamed into the Republican Specialized Scientific and Practical Medical Endocrinological Center.
2005-2007	A technical cooperation program has been implemented between the International Atomic Energy Agency (IAEA) and the Ministry of Health of the Republic of Uzbekistan (C6 / UZB / 006). In July 2007, the Nucline TM SPIRIT DH-V two-head camera was installed and put into operation. With its help, the Center significantly expanded functional research of parenchymal organs: thyroid gland, liver, kidneys, spleen, heart, brain, skeletal system, research is being carried out with computerized storage of databases from all over the Republic. In-line study (dynamic and statistical study of the kidneys, renography, scanning of the thyroid and parathyroid glands), also SPECT studies (single-photon emission computed tomography) of bones, heart, lungs, whole-body study after radioiodine therapy in patients with thyroid thyroid cancer
2008	Close scientific and practical cooperation has been established with scientists from Great Britain.
2009	Based on the Resolution of the Cabinet of Ministers dated May 25, 2009, No. 145 and orders of the Ministry of Health of the Republic of Uzbekistan No. 160 dated June 01, 2009, No. 347 dated November 20, 2009, the tasks are defined and the activities of the RSNPMC Endocrinology, as the leading medical institution providing an effective vertical management and interactions within the industry and continuity between endocrinological institutions
2012	Reconstruction of a non-functioning center building into a diabetic nephropathy department with hemodialysis therapy has been completed
2009-2013	In the implementation of the plan - measures for the implementation of the Decree of the President of the Republic of Uzbekistan No. PP-1096 of April 13, 2009 "On additional measures to protect the health of mothers and children, the formation of a healthy generation" for the creation of model SVPs, the staff of the associations carried out a number of works to improve the material and technical base of the SVP (for 5 years, 50 SVP).
2013	Neurosurgical operational activity began in 2011, when transsphenoidal interventions on the pituitary gland were introduced into the practice of the Center. The surgical block was reconstructed with the creation of two operating compartments for endocrine surgery and transsphenoidal pituitary surgery. In April 2013, by order of the Ministry of Health of the Republic of Uzbekistan, the Department of Neurosurgery was opened at the Center of Endocrinology, where high-tech operations are performed not only on the pituitary gland, but on the spine.
2018	In accordance with the Decree of the President of the Republic of Uzbekistan dated October 30, 2017 No. UP-5216 "On amendments and additions to some acts of the President of the Republic of Uzbekistan", Resolution of the President of the Republic of Uzbekistan No. PP-3071 dated June 20, 2017 "On measures for the further development of specialized medical care to the population of the Republic of Uzbekistan for 2017-2021 ", the Republican Specialized Scientific and Practical Medical Center of Endocrinology was renamed into the State Institution" Republican Specialized Scientific and Practical Medical Center of Endocrinology named after academician Y.Kh. Turakulova ".
2018	The scientific potential of the Center employs 45 employees, including 37 researchers. The institute has 6 scientific laboratories, a clinic with 13 departments for 288 beds, a polyclinic for 250 visits, an organizational method department and other departments.
	For 2012-2017, 11 scientific grants were carried out at the Endocrinology Center, including 2 fundamental, 5 applied, 2 innovative and 2 grants of young scientists. The total amount of funding for scientific grants over the past 5 years amounted to 4.150.214 thousand soums.
	Over a 5-year period, 215 publications have been published and 8 computer programs have been developed (for the register of patients with diabetes mellitus, diabetes insipidus, Cushing's syndrome, inactive pituitary adenomas, metabolic syndrome in children and adolescents, a calculator of the risk of myocardial infarction in patients with type 2 diabetes, etc. ), 11 methodological recommendations, 14 manuals and manuals, 126 articles (of which 82 are in foreign publications and 44 in local ones) and 64 theses (of which 45 are foreign and 19 are local). Of the 126 published articles, 62 (49.2%) were published in impact factor journals. Of these, 27 at Googlescholar, 24 at RSCI and 11 at Webofscience / Scopus.
2017-2018.	RSNPMCE has carried out some work to establish and expand international cooperation with leading foreign medical universities, centers and clinics from the Russian Federation, USA, Republic of Korea, Turkey, Great Britain, France, Czech Republic, Estonia, Ukraine, Azerbaijan and other countries. In total, today the RSNPMCE has 12 valid Memorandums with foreign medical centers, clinics, as well as pharmaceutical companies for cooperation in the field of medical science.
2017	The "Clinical protocols for the diagnosis and treatment of endocrine diseases for doctors of all levels of health care" (for 7 nosologies) were approved. Order of the Ministry of Health of the Republic of Uzbekistan No. 457 dated August 16, 2017. The "Standards for the diagnosis and treatment of endocrine diseases" with appendices were approved. The standards are designed for physicians at all levels of healthcare. Order of the Ministry of Health of the Republic of Uzbekistan No. 457 dated August 16, 2017.
2018	The order of the Ministry of Health of the Republic of Uzbekistan No. 165 "On measures to improve the endocrinological service of the Republic of Uzbekistan" dated 14.03.2018 was approved (update of order No. 589 dated 13.11.1992. Changes have been made to the structure of the dispensary, to the equipment list of not only the dispensary, but also specialized departments of the RMO. On the basis of the changes made, changes were made to the structure of the existing staffing standards of the dispensary and submitted for consideration to the Ministry of Health of the Republic of Uzbekistan).
2018	"Clinical protocols for the diagnosis and treatment of endocrine diseases for doctors of all levels of health care" (for 23 nosologies) were approved. Order of the Ministry of Health of the Republic of Uzbekistan No. 468 dated 07.19.2018.
2018	In the RSNPMTSE named after academician Y.Kh. Turakulova opened a new department "Clinical Endocrinology" for 26 beds
	The Center has a central server that unites more than 200 computers. A user-friendly special software product has been developed and implemented, which allows you to save in electronic form all information about patients visited by the Center. There is constant access to the Internet.
2017-2018	The local network of the Center has been improved and a local network system has been introduced with all regions of the Republic to create a unified database on endocrine service. In 2017, 507 patients from different areas were consulted on telemedicine, and appropriate recommendations were given on further management tactics. During 2018, the leading employees of the Center consulted 962 patients from different regions of the Republic.
2018	The Kashkadarya branch of the RSNPMTSE named after academician Y.Kh. Turakulov with 150 beds and 150 visits, Navoi Endocrinology Dispensary (after the construction of a new building) with 85 beds, 100 visits was opened
2019	The new staff standards of the regional, city endocrinological dispensary of the Ministry of Health of the Republic of Uzbekistan from 04.03.2019 were approved. With the approval of the Ministry of Employment and Labor Relations of the Republic and the Ministry of Finance of the Republic of Uzbekistan
2019	The Resolution of the President of the Republic of Uzbekistan No. PP 4295 of 19.04.2019 "On measures to improve the system of rendering specialized endocrinological service of the Republic of Uzbekistan" has been issued
2019 04.24.	The Namangan branch of the RSNPMTSE named after academician Y.Kh. Turakulova, 160 beds, 150 visits